Catherine Ann Keener (born March 23, 1959) is an American actress. She has been twice nominated for the Academy Award for Best Supporting Actress for her roles as Maxine Lund in Being John Malkovich (1999) and Harper Lee in Capote (2005).

Keener also appeared in the films The 40-Year-Old Virgin (2005), Into the Wild (2007), Synecdoche, New York (2008), and Get Out (2017), which were all well received by critics. Keener is the muse of director Nicole Holofcener, having appeared in each of Holofcener's first five films. She also appeared in each of director Tom DiCillo's first four films, and three films directed by Spike Jonze.