Irene Ryan (born Jessie Irene Noblitt; October 17, 1902 – April 26, 1973) was an American actress who found success in vaudeville, radio, film, television, and Broadway.

Ryan is most widely known for her portrayal of Granny, the mother-in-law of Buddy Ebsen's character, on the long-running TV series The Beverly Hillbillies (1962–1971), for which she was nominated for Emmy Awards for Outstanding Lead Actress in a Comedy Series in 1963 and 1964.