Janeane Garofalo (; born September 28, 1964) is an American actress, stand-up comedian, and writer.

Garofalo began her career as a stand-up comedian and became a cast member on The Ben Stiller Show, The Larry Sanders Show, and Saturday Night Live, then appeared in more than 50 movies, with leading or major roles in The Truth About Cats and Dogs, Wet Hot American Summer, The Matchmaker, Reality Bites, Steal This Movie!, Clay Pigeons, Sweethearts, Mystery Men, and The Independent, among numerous others. She has been a series regular on television programs such as Wet Hot American Summer: First Day of Camp, 24, and Girlfriends' Guide to Divorce.

Garofalo is an outspoken progressive activist. From March 2004 to July 2006, she hosted Air America Radio's The Majority Report with Sam Seder.